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Title: Translational mini-review series on Th17 cells: are T helper 17 cells really pathogenic in autoimmunity?
Author(s): Koenders, M.I. ; Berg, W.B. van den
Publication year: 2010
Source: Clinical and Experimental Immunology, vol. 159, iss. 2, (2010), pp. 131-136
ISSN: 0009-9104
DOI: http://dx.doi.org/10.1111/j.1365-2249.2009.04039.x
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/87612   https://hdl.handle.net/2066/87612

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Subject: N4i 4: Auto-immunity, transplantation and immunotherapy
NCMLS 1: Infection and autoimmunity
Organization: Rheumatology
Journal title:
Clinical and Experimental Immunology
Volume: vol. 159
Issue: iss. 2
Page start: p. 131
Page end: p. 136
Abstract:
In this review the authors discuss the evidence for T helper type 17 (Th17) cells as pathogenic T cells in autoimmunity. Studies with cytokine-deficient mice or blocking of interleukin (IL)-17, IL-21 and IL-22 have resulted in a conflicting data set. Although in the experimental autoimmune encephalomyelitis model the role of Th17 cells remains a point of debate, this IL-17-producing T cell in experimental arthritis is clearly contributing to inflammation and destruction.

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