Subject:
|
N4i 4: Auto-immunity, transplantation and immunotherapy NCMLS 1: Infection and autoimmunity |
Journal title:
|
Clinical and Experimental Immunology
|
Abstract:
|
In this review the authors discuss the evidence for T helper type 17 (Th17) cells as pathogenic T cells in autoimmunity. Studies with cytokine-deficient mice or blocking of interleukin (IL)-17, IL-21 and IL-22 have resulted in a conflicting data set. Although in the experimental autoimmune encephalomyelitis model the role of Th17 cells remains a point of debate, this IL-17-producing T cell in experimental arthritis is clearly contributing to inflammation and destruction.
|