Maternal homocysteine and related B vitamins as risk factors for low birthweight.
until further notice
SourceAmerican Journal of Obstetrics and Gynecology, 202, 6, (2010), pp. 572.e1-6
1 juni 2010
Article / Letter to editor
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Paediatrics - OUD tm 2017
Epidemiology, Biostatistics & HTA
American Journal of Obstetrics and Gynecology
SubjectIGMD 5: Health aging / healthy living; IGMD 6: Hormonal regulation; NCEBP 1: Molecular epidemiology
OBJECTIVE: We designed a large prospective study to explore the relationship between maternal homocysteine concentrations and related B vitamins and birthweight. STUDY DESIGN: Blood was sampled from pregnant women at 30-34 weeks of gestation and their newborn infants (n = 366). RESULTS: Concentrations of all analytes were higher in umbilical cord compared with maternal samples. Birthweight was related negatively to maternal homocysteine (r = -0.12) but not related to maternal cobalamin, methylmalonic acid, and folate (r = 0.02, r = 0.06, and r = 0.04, respectively). Regression analysis revealed smoking (beta = -313; 95% confidence interval [CI], -479 to -149), gestational age (beta = 150; 95% CI, 118-182), female sex (beta = -146; 95% CI, -256 to -35), and parity (beta = 104; 95% CI, 37-171) as strong determinants of birthweight. Maternal homocysteine, cobalamin, methylmalonic acid, and folate were not determinants of birthweight in multivariate analysis. CONCLUSION: Maternal homocysteine and B vitamins are not related to birthweight in a multivariate model that was adjusted for potential confounders.
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