Novel powerful water-soluble lipid immunoadjuvants inducing mouse dendritic cell maturation and B cell proliferation using TLR2 pathway.
SourceBioorganic & Medicinal Chemistry Letters, 20, 6, (2010), pp. 1869-1872
Article / Letter to editor
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Bioorganic & Medicinal Chemistry Letters
SubjectIGMD 8: Mitochondrial medicine; NCMLS 5: Membrane transport and intracellular motility
Four novel water-soluble lipid immunoadjuvants were designed, synthesized and characterized by MS and NMR. They all induce mouse dendritic cell maturation and B cell proliferation. We demonstrate that in spite of the chemical modification, the four compounds remain TLR2 agonists.
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