Novel powerful water-soluble lipid immunoadjuvants inducing mouse dendritic cell maturation and B cell proliferation using TLR2 pathway.
Publication year
2010Source
Bioorganic & Medicinal Chemistry Letters, 20, 6, (2010), pp. 1869-72ISSN
Publication type
Article / Letter to editor

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Organization
Pharmacology-Toxicology
Journal title
Bioorganic & Medicinal Chemistry Letters
Volume
vol. 20
Issue
iss. 6
Page start
p. 1869
Page end
p. 72
Subject
IGMD 8: Mitochondrial medicine; NCMLS 5: Membrane transport and intracellular motilityAbstract
Four novel water-soluble lipid immunoadjuvants were designed, synthesized and characterized by MS and NMR. They all induce mouse dendritic cell maturation and B cell proliferation. We demonstrate that in spite of the chemical modification, the four compounds remain TLR2 agonists.
This item appears in the following Collection(s)
- Academic publications [227030]
- Faculty of Medical Sciences [86563]
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