Gamma-phase shifting in awake monkey visual cortex
Number of pages
SourceThe Journal of Neuroscience, 30, 4, (2010), pp. 1250-1257
Article / Letter to editor
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Donders Centre for Cognitive Neuroimaging
PI Group MR Techniques in Brain Function
F.C. Donders Centre for Cognitive Neuroimaging
The Journal of Neuroscience
Subject120 000 Neuronal Coherence; 120 003 Role of neuronal synchrony in multi-modal integration; Biophysics
Gamma-band synchronization is abundant in nervous systems. Typically, the strength or precision of gamma-band synchronization is studied. However, the precise phase with which individual neurons are synchronized to the gamma-band rhythm might have interesting consequences for their impact on further processing and for spike timing-dependent plasticity. Therefore, we investigated whether the spike times of individual neurons shift systematically in the gamma cycle as a function of the neuronal activation strength. We found that stronger neuronal activation leads to spikes earlier in the gamma cycle, i.e., we observed gamma-phase shifting. Gamma-phase shifting occurred on very rapid timescales. It was particularly pronounced for periods in which gamma-band synchronization was relatively weak and for neurons that were only weakly coupled to the gamma rhythm. We suggest that gamma-phase shifting is brought about by an interplay between overall excitation and gamma-rhythmic synaptic input and has interesting consequences for neuronal coding, competition, and plasticity.
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