
Fulltext:
81921.pdf
Embargo:
until further notice
Size:
182.0Kb
Format:
PDF
Description:
publisher's version
Publication year
2009Source
Cerebrovascular Diseases, 28, 6, (2009), pp. 551-557ISSN
Publication type
Article / Letter to editor

Display more detailsDisplay less details
Organization
Donders Centre for Cognitive Neuroimaging
IQ Healthcare
Neurology
Medical Psychology
Former Organization
F.C. Donders Centre for Cognitive Neuroimaging
Journal title
Cerebrovascular Diseases
Volume
vol. 28
Issue
iss. 6
Page start
p. 551
Page end
p. 557
Subject
130 008 Post stroke memory dysfunction; DCN 1: Perception and Action; NCEBP 8: Psychological determinants of chronic illness; NCEBP 8: Psychological determinants of chronic illnessAbstract
BACKGROUND: Several studies have described the frequency and risk factors of post-stroke depressive symptoms (PSDS). However, most studies did not exclude patients with depressive symptoms shortly before stroke and paid little attention to prestroke risk factors of depression, including previous depressive episodes, white matter lesions, and brain atrophy. These are potential limitations to assess the true effect of stroke on the occurrence of depressive symptoms. Our aim was to investigate the prevalence and risk factors of PSDS with adjustments for the previously mentioned prestroke factors. METHODS: 420 consecutive patients with an acute clinical symptomatic transient ischemic attack or cerebral infarction were eligible for enrolment in this study. The presence of PSDS was rated by the Hospital Anxiety and Depression Scale 6-8 weeks after stroke. The relation between (pre-) stroke factors and PSDS was assessed with multivariate regression analysis. Results : The prevalence of PSDS was 13% and did not differ between stroke subtype or first-ever/ever occurrence of stroke. Higher degree of post-stroke handicap was related to PSDS (OR = 5.39; 95% CI = 2.40-12.08) and more functional independence had a protective effect on PSDS (OR = 0.88; 95% CI = 0.77-1.00). CONCLUSIONS: This is the largest study that investigated the prevalence and risk factors of PSDS by carefully excluding patients with depressive symptoms shortly before stroke. PSDS were not related to lesion side or location, but to the degree of post-stroke handicap and functional independence. Early detection of PSDS and their risk factors might help to predict long-term outcome and could promote early interventions of (behavioral) rehabilitation treatment strategies.
This item appears in the following Collection(s)
- Academic publications [202914]
- Donders Centre for Cognitive Neuroimaging [3357]
- Electronic publications [101091]
- Faculty of Medical Sciences [80065]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.