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Title: Serum vascular endothelial growth factor: a prognostic factor in cervical cancer.
Author(s): Zusterzeel, P.L.M. ; Span, P.N. ; Dijksterhuis, M.G.; Thomas, C.M.G. ; Sweep, F.C. ; Massuger, L.F.A.G.
Publication year: 2009
Source: Journal of Cancer Research and Clinical Oncology, vol. 135, iss. 2, (2009), pp. 283-290
ISSN: 0171-5216
DOI: http://dx.doi.org/10.1007/s00432-008-0442-y
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/81567   http://hdl.handle.net/2066/81567

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Subject: IGMD 6: Hormonal regulation
ONCOL 1: Hereditary cancer and cancer-related syndromes
ONCOL 3: Translational research
ONCOL 5: Aetiology, screening and detection
Organization: Gynaecology
Chemical Endocrinology
Radiation Oncology
Laboratory of Genetic, Endocrine and Metabolic Diseases
Journal title:
Journal of Cancer Research and Clinical Oncology
Volume: vol. 135
Issue: iss. 2
Page start: p. 283
Page end: p. 290
Abstract:
PURPOSE: To study pre-treatment serum VEGF of patients with invasive cervical cancer and its possible role as prognostic indicator. METHODS: VEGF was measured using ELISA in the largest patient group (n = 167) to date. Results : Serum VEGF was significantly higher in advanced tumor stage (P = 0.01), large tumor size (tumors larger than 2 cm) (P = 0.03), and the presence of vascular space invasion (P = 0.05). Serum VEGF was associated with disease free and overall survival [DFS: Hazard Ratio (HR) = 2.61; 95% CI 1.32-5.17; P = 0.006; for OS: HR = 2.09; 95% CI 1.54-2.84; P < 0.001, respectively]. In multivariate Cox regression serum VEGF retained its prognostic value for DFS (HR = 2.10, P = 0.03) and OS (HR = 1.92, P = 0.04). CONCLUSIONS: Serum VEGF levels correlate with more advanced and more aggressive disease in cervical cancer and may be a useful prognostic factor in patients with cervical cancer.

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