The Plasmodium falciparum var gene transcription strategy at the onset of blood stage infection in a human volunteer.

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Title:	The Plasmodium falciparum var gene transcription strategy at the onset of blood stage infection in a human volunteer.
Author(s):	Wang, C.W.; Hermsen, C.C. ; Sauerwein, R.W. ; Arnot, D.E.; Theander, T.G.; Lavstsen, T.
Publication year:	2009
Source:	Parasitology International, vol. 58, iss. 4, (2009), pp. 478-480
ISSN:	1383-5769
DOI:	https://doi.org/10.1016/j.parint.2009.07.004
Publication type:	Article / Letter to editor
Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/81359
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Subject:	N4i 3: Poverty-related infectious diseases NCMLS 1: Infection and autoimmunity
Organization:	Medical Microbiology
Journal title:	Parasitology International
Volume:	vol. 58
Issue:	iss. 4
Page start:	p. 478
Page end:	p. 480
Abstract:	The var genes encode a family of adhesion receptor proteins, Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), which profoundly influence malaria pathogenesis. Only a single var gene is transcribed and one PfEMP1 expressed per P.falciparum parasite. Here we present the in vivo transcript distribution of var genes in a P. falciparum-infected non-immune individual and show that the initial expression of PfEMP1 is based on a strategy that allows all or most variants of PfEMP1s to be expressed by the parasite population at the onset of the blood stage infection.