The influence of the use of CT-planning on the irradiated boost volume in breast conserving treatment.
Publication year
2009Source
Radiotherapy and Oncology, 93, 1, (2009), pp. 87-93ISSN
Publication type
Article / Letter to editor
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Organization
Radiation Oncology
Journal title
Radiotherapy and Oncology
Volume
vol. 93
Issue
iss. 1
Page start
p. 87
Page end
p. 93
Subject
ONCOL 3: Translational researchAbstract
BACKGROUND AND PURPOSE: The purpose of this study was to investigate the effect of CT-based delineation and planning on the irradiated boost volume. For this specific purpose we used the data as derived from 2 prospective phase III randomised trials. PATIENTS AND METHODS: Data from 1331 patients (<or=50 years) were analyzed with a reported boost volume from a simulation-based treatment plan (EORTC boost vs no boost trial, n=922), and a CT-scan-based treatment plan (Young Boost Trial, n=409) group. Tumour diameter, irradiation technique (photons vs electrons), lumpectomy size, and age were used as covariates. RESULTS: Median V(95%) in the conventional simulation-based treatment plans was 99 cc (range 9-628) for photons and was 98 cc (13-651) for electrons, whereas in the CT-planned patients, these figures were 178 cc (37-2699) and 150 cc (43-1272), respectively. Multivariable analysis showed an association of the irradiated boost volume with tumour size (p<0.0067), lumpectomy size (p<0.0002), and boost technique (p<0.0004). The use of a CT-scan for volume delineation and treatment planning remained significant (p<0.0001). CONCLUSIONS: The use of a CT-scan for delineation and treatment planning led to a significant increase of the irradiated boost volume by a factor of 1.5-1.8, compared to conventional simulator-based plans.
This item appears in the following Collection(s)
- Academic publications [238441]
- Faculty of Medical Sciences [90373]
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