Value of Candida serum markers in patients with invasive candidiasis after myeloablative chemotherapy.

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Publication year
2009Source
Diagnostic Microbiology and Infectious Diseases, 64, 4, (2009), pp. 408-415ISSN
Publication type
Article / Letter to editor

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Organization
Medical Microbiology
Haematology
Journal title
Diagnostic Microbiology and Infectious Diseases
Volume
vol. 64
Issue
iss. 4
Page start
p. 408
Page end
p. 415
Subject
N4i 2: Invasive mycoses and compromised host; NCMLS 1: Infection and autoimmunityAbstract
Invasive Candida infections are associated with a significant morbidity and mortality. Detection of circulating biomarkers has been shown to precede conventional diagnostic methods, which is important in improving outcome. We investigated the performance of multiple biomarkers using Candida antigen and anti-Candida antibody detection systems of Platelia and Serion and beta-d-glucan detection in serial serum samples from patients, treated for leukemia, with invasive candidiasis. The performance of single assays and combined detection appeared different for patients with 1 or more episodes of neutropenia and is therefore related to the phase of therapy for the underlying leukemia of the patient. These new insights may help to optimize the diagnostic strategies for the diagnosis of invasive candidiasis.
This item appears in the following Collection(s)
- Academic publications [203793]
- Electronic publications [102109]
- Faculty of Medical Sciences [80320]
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