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Title: Value of Candida serum markers in patients with invasive candidiasis after myeloablative chemotherapy.
Author(s): Lunel, F.M.; Mennink-Kersten, M.A.S.H.; Ruegebrink, D. ; Lee, H.A.L. van der ; Donnelly, J.P. ; Blijlevens, N.M.A. ; Verweij, P.E.
Publication year: 2009
Source: Diagnostic Microbiology and Infectious Diseases, vol. 64, iss. 4, (2009), pp. 408-415
ISSN: 0732-8893
DOI: https://doi.org/10.1016/j.diagmicrobio.2009.04.012
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/80959   https://hdl.handle.net/2066/80959

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Subject: N4i 2: Invasive mycoses and compromised host
NCMLS 1: Infection and autoimmunity
Organization: Medical Microbiology
Haematology
Journal title:
Diagnostic Microbiology and Infectious Diseases
Volume: vol. 64
Issue: iss. 4
Page start: p. 408
Page end: p. 415
Abstract:
Invasive Candida infections are associated with a significant morbidity and mortality. Detection of circulating biomarkers has been shown to precede conventional diagnostic methods, which is important in improving outcome. We investigated the performance of multiple biomarkers using Candida antigen and anti-Candida antibody detection systems of Platelia and Serion and beta-d-glucan detection in serial serum samples from patients, treated for leukemia, with invasive candidiasis. The performance of single assays and combined detection appeared different for patients with 1 or more episodes of neutropenia and is therefore related to the phase of therapy for the underlying leukemia of the patient. These new insights may help to optimize the diagnostic strategies for the diagnosis of invasive candidiasis.

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