Evaluation of different normalization procedures for the calculation of the standardized uptake value in therapy response monitoring studies.

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Publication year
2009Source
Nuclear Medicine Communications, 30, 7, (2009), pp. 550-7ISSN
Publication type
Article / Letter to editor

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Organization
Nuclear Medicine
Medical Oncology
Radiology
Pulmonary Diseases
Health Evidence
Former Organization
Epidemiology, Biostatistics & HTA
Journal title
Nuclear Medicine Communications
Volume
vol. 30
Issue
iss. 7
Page start
p. 550
Page end
p. 7
Subject
N4i 1: Pathogenesis and modulation of inflammation; NCEBP 2: Evaluation of complex medical interventions; ONCOL 2: Age-related aspects of cancer; ONCOL 3: Translational research; ONCOL 4: Quality of Care; ONCOL 5: Aetiology, screening and detectionAbstract
OBJECTIVES: The aim of this prospective study was to assess the influence of different normalization procedures on relative changes in standardized uptake values (SUV) of F-2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) for the assessment of chemotherapy response in patients with colorectal carcinoma (CRC) and nonsmall cell lung carcinoma (NSCLC). METHODS: In 97 patients with CRC (n = 48) and NSCLC (n = 49), FDG-PET was performed before and during the course of chemotherapy. Relative changes in SUV (DeltaSUV) were determined after correction for injected dose and bodyweight, lean body mass, body surface area or a combination of bodyweight and plasma glucose. The predictive value for overall and progression-free survival with respect to the different normalized DeltaSUVs was assessed. RESULTS: In both CRC and NSCLC, no differences were seen in the degree of change between the four SUV-normalizations during chemotherapy. Cox regression analysis for overall survival showed significant hazard ratios of 1.14-1.16 per 10% SUV change in CRC and 1.10-1.13 in NSCLC and for progression-free survival hazard ratios of 1.15 per 10% DeltaSUV change in CRC and 1.10-1.12 in NSCLC. CONCLUSION: Relative changes in SUV is a strong predictor for survival in both CRC and NSCLC. None of the four normalization methods showed statistical advantage over the other. Therefore, simplifying the methods for analysis of FDG-PET data can improve the incorporation of FDG-PET in clinical treatment-response monitoring and may facilitate application in multicentre trials.
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- Academic publications [227693]
- Electronic publications [107311]
- Faculty of Medical Sciences [86198]
- Open Access publications [76438]
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