
Fulltext:
80712.pdf
Embargo:
until further notice
Size:
298.0Kb
Format:
PDF
Description:
publisher's version
Publication year
2009Source
Pediatric Critical Care Medicine, 10, 2, (2009), pp. 227-233ISSN
Publication type
Article / Letter to editor

Display more detailsDisplay less details
Organization
Intensive Care
Paediatrics
Journal title
Pediatric Critical Care Medicine
Volume
vol. 10
Issue
iss. 2
Page start
p. 227
Page end
p. 233
Subject
IGMD 1: Functional imaging; N4i 1: Pathogenesis and modulation of inflammation; N4i 1: Pathogenesis and modulation of inflammationAbstract
OBJECTIVE: Measurement of extravascular lung water (EVLW) may be useful in the treatment of critically ill children and can be performed at the bedside using the transpulmonary thermodilution technique (TPTD). There are currently no data to verify the accuracy of these measurements in (small) children. We compared the results of TPTD measurement with the clinical gold standard transpulmonary double indicator dilution (TPDD) measurement in young children. DESIGN: Prospective clinical study in children. SETTING: Catheterization laboratory of a university hospital. PATIENTS AND METHODS: Twelve children (<2 yrs or <12 kg) under general anesthesia. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Measurements were performed using injections of ice-cold indicator (saline or dye) through a central venous catheter. Mean cardiac index was 3.91 L/min/m, mean intrathoracic blood volume index (ITBVITPDD) was 614.9 mL/m, and mean extravascular lung water index (EVLWITPDD) was 11.7 mL/kg. The correlation coefficient between EVLWITPDD and EVLWITPTD is 0.96 (95% confidence interval: 0.87-0.99; p < 0.0001). Bland-Altman analysis for EVLW measurements showed a mean bias of 2.34 mL/kg (18.13%) and limits of agreement +/-2.97 mL/kg (19.78%). The difference between measurements via the right atrium compared with the femoral vein was 2.8% for cardiac output, 8.2% for global end-diastolic volume, and 0.1% for EVLW. CONCLUSION: Clinical measurement of EVLW in young children can be performed using the TPTD with the injection catheter inserted in the femoral vein. Further studies are needed to clarify the clinical value of these measurements.
This item appears in the following Collection(s)
- Academic publications [204994]
- Electronic publications [103280]
- Faculty of Medical Sciences [81051]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.