Feasibility of concurrent dual contrast enhancement using CEST contrast agents and superparamagnetic iron oxide particles.

Fulltext:
80681_pub.pdf
Embargo:
until further notice
Size:
643.0Kb
Format:
PDF
Description:
publisher's version
Publication year
2009Source
Magnetic Resonance in Medicine, 61, 4, (2009), pp. 970-4ISSN
Publication type
Article / Letter to editor

Display more detailsDisplay less details
Organization
Radiology
Medical Oncology
Journal title
Magnetic Resonance in Medicine
Volume
vol. 61
Issue
iss. 4
Page start
p. 970
Page end
p. 4
Subject
NCMLS 4: Energy and redox metabolism; ONCOL 3: Translational research; ONCOL 4: Quality of Care; ONCOL 5: Aetiology, screening and detectionAbstract
A major challenge for cellular and molecular MRI is to study interactions between two different cell populations or biological processes. We studied the possibility to simultaneously image contrast agents based on two different MRI contrast mechanisms: chemical exchange saturation transfer (CEST) and enhancement of T2 relaxation. Various amounts of superparamagnetic iron oxide (SPIO) nanoparticles were mixed with a fixed concentration (250 microM) of the CEST agent poly-L-lysine. T2 maps, CEST maps, and frequency-dependent saturation spectra were then measured. Color-coded overlay maps demonstrated the feasibility of concurrent dual contrast enhancement. We found that at concentrations lower than 5 microg(Fe)/mL both contrast agents can be imaged simultaneously. At higher concentrations, the iron-based agent can be used to "shut off" the signal arising from the CEST agent. These initial findings are a first step toward using dual CEST/T2 contrast imaging for studying multiple cellular or molecular targets simultaneously in vivo.
This item appears in the following Collection(s)
- Academic publications [227613]
- Electronic publications [107273]
- Faculty of Medical Sciences [86193]
- Open Access publications [76399]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.