Azole-resistant central nervous system aspergillosis.
until further notice
SourceClinical Infectious Diseases, 48, 8, (2009), pp. 1111-1113
Article / Letter to editor
Display more detailsDisplay less details
Clinical Infectious Diseases
SubjectN4i 2: Invasive mycoses and compromised host; NCMLS 1: Infection and autoimmunity
Three patients with central nervous system aspergillosis due to azole-resistant Aspergillus fumigatus (associated with a leucine substitution for histidine at codon 98 [L98H] and a 34-base pair repeat in tandem in the promoter region) are described. The patients were treated with combination therapy or with polyenes, but all patients died. Azole resistance significantly complicates the management of aspergillosis by delaying the initiation of adequate therapy and because effective alternative antifungal drugs are lacking.
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.