Cannabis coadministration potentiates the effects of "ecstasy" on heart rate and temperature in humans.
until further notice
SourceClinical Pharmacology and Therapeutics, 86, 2, (2009), pp. 160-166
Article / Letter to editor
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Laboratory of Genetic, Endocrine and Metabolic Diseases
PI Group Memory and Emotion
F.C. Donders Centre for Cognitive Neuroimaging
Clinical Pharmacology and Therapeutics
Subject110 012 Social cognition of verbal communication; 150 000 MR Techniques in Brain Function; DCN 1: Perception and Action; IGMD 5: Health aging / healthy living; IGMD 6: Hormonal regulation; NCEBP 14: Cardiovascular diseases; NCEBP 2: Evaluation of complex medical interventions; NCEBP 9: Mental health; ONCOL 3: Translational research; ONCOL 5: Aetiology, screening and detection
This study assessed the acute physiologic effects over time of (co)administration of Delta9-tetrahydrocannabinol (Delta9-THC) (the main psychoactive compound of cannabis) and 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") in 16 healthy volunteers. Pharmacokinetics and cardiovascular, temperature, and catecholamine responses were assessed over time. Both single-drug conditions robustly increased heart rate, and coadministration showed additive effects. MDMA increased epinephrine and norepinephrine concentrations, whereas THC did not affect the catecholamine response. Coadministration of MDMA and THC attenuated the increase of norepinephrine concentrations relative to administration of MDMA alone. These results show that THC mediates heart rate increase independent of sympathetic (catecholaminergic) activity, probably through direct cannabinoid receptor type 1 (CB(1)) agonism in cardiac tissue. Furthermore, THC coadministration did not prevent MDMA-induced temperature increase, but it delayed the onset and prolonged the duration of temperature elevation. These effects may be of particular relevance for the cardiovascular safety of ecstasy users who participate in energetic dancing in nightclubs with high ambient temperature.
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