Arteriovenous fistulae as an alternative to central venous catheters for delivery of long-term home parenteral nutrition.
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Publication year
2009Source
Gastroenterology, 136, 5, (2009), pp. 1577-84ISSN
Publication type
Article / Letter to editor
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Organization
Gastroenterology
IQ Healthcare
Health Evidence
Surgery
Former Organization
Centre for Quality of Care Research
Epidemiology, Biostatistics & HTA
Journal title
Gastroenterology
Volume
vol. 136
Issue
iss. 5
Page start
p. 1577
Page end
p. 84
Subject
IGMD 1: Functional imaging; IGMD 2: Molecular gastro-enterology and hepatology; NCEBP 14: Cardiovascular diseases; NCEBP 2: Evaluation of complex medical interventions; NCEBP 6: Quality of nursing and allied health careAbstract
BACKGROUND & AIMS: The success of home parenteral nutrition (HPN) programs is compromised by complications of central venous catheters (CVCs), such as occlusions and bloodstream infections. We performed a retrospective analysis of complication rates of arteriovenous fistulae versus CVCs in patients on long-term HPN. METHODS: Data were collected from 127 consecutive patients who received HPN between January 2000 and October 2006, comprising 344 access years of CVCs and 194 access years of arteriovenous fistulae. We evaluated access-related bloodstream infection and occlusion incidence rates (number of complications per access year) using Poisson-normal regression analysis. Complication incidence rate ratios were calculated by dividing complication incidence rates of CVCs by those of arteriovenous fistulae, adjusting for HPN frequency, medication use, infusion fluid composition, and underlying diseases. RESULTS: Bloodstream infection incidence rates were 0.03/year for arteriovenous fistulae, 1.37/year for long-term CVCs (Port-a-Caths and tunneled catheters), and 3.12/year for short-term CVCs (nontunneled catheters). Occlusion incidence rates were 0.60/year for arteriovenous fistulae, 0.35/year for long-term CVCs, and 0.93/year for shortterm CVCs. Adjusted incidence rate ratios of long-term CVCs over arteriovenous fistulae were 47 (95% confidence interval, 19-117) for bloodstream infections and 0.53 (95% confidence interval, 0.31-0.89) for occlusions. CONCLUSIONS: The occlusion incidence rate was higher for arteriovenous fistulae than for certain types of CVCs. The incidence rate of the most serious access-related complication (bloodstream infections) was much lower for arteriovenous fistulae than for all types of CVCs. Thus, arteriovenous fistulae are safe and valuable alternatives to CVCs for patients requiring long-term HPN.
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- Faculty of Medical Sciences [90373]
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