DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice.

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Publication year
2009Source
Neurobiology of Disease, 33, 3, (2009), pp. 482-498ISSN
Publication type
Article / Letter to editor

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Organization
Central Animal Laboratory
Cell Biology (UMC)
Cognitive Neuroscience
Anatomy
Biochemistry (UMC)
Radiology
Former Organization
Medical Physics and Biophysics
Journal title
Neurobiology of Disease
Volume
vol. 33
Issue
iss. 3
Page start
p. 482
Page end
p. 498
Subject
DCN 2: Functional Neurogenomics; DCN 3: Neuroinformatics; IGMD 8: Mitochondrial medicine; NCMLS 3: Tissue engineering and pathology; NCMLS 4: Energy and redox metabolism; ONCOL 3: Translational research; ONCOL 5: Aetiology, screening and detectionAbstract
Cholesterol and docosahexenoic acid (DHA) may affect degenerative processes in Alzheimer's Disease (AD) by influencing Abeta metabolism indirectly via the vasculature. We investigated whether DHA-enriched diets or cholesterol-containing Typical Western Diets (TWD) alter behavior and cognition, cerebral hemodynamics (relative cerebral blood volume (rCBV)) and Abeta deposition in 8- and 15-month-old APP(swe)/PS1(dE9) mice. In addition we investigated whether changes in rCBV precede changes in Abeta deposition or vice versa. Mice were fed regular rodent chow, a TWD-, or a DHA-containing diet. Behavior, learning and memory were investigated, and rCBV was measured using contrast-enhanced MRI. The Abeta load was visualized immunohistochemically. We demonstrate that DHA altered rCBV in 8-month-old APP/PS1 and wild type mice[AU1]. In 15-month-old APP/PS1 mice DHA supplementation improved spatial memory, decreased Abeta deposition and slightly increased rCBV, indicating that a DHA-enriched diet can diminish AD-like pathology. In contrast, TWD diets decreased rCBV in 15-month-old mice. The present data indicate that long-term dietary interventions change AD-like pathology in APP/PS1 mice. Additionally, effects of the tested diets on vascular parameters were observed before effects on Abeta load were noted. These data underline the importance of vascular factors in the APP/PS1 mouse model of AD pathology.
This item appears in the following Collection(s)
- Academic publications [204996]
- Electronic publications [103294]
- Faculty of Medical Sciences [81051]
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