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Title: Metastatic potential of an aneurysmal bone cyst.
Author(s): Luijtgaarden, A.C.M. van de ; Veth, R.P.H. ; Slootweg, P.J. ; Wijers-Koster, P.M.; Schultze Kool, L.J. ; Bovee, J.V.; Graaf, W.T.A. van der
Publication year: 2009
Source: Virchows Archiv, vol. 455, iss. 5, (2009), pp. 455-459
ISSN: 0945-6317
DOI: https://doi.org/10.1007/s00428-009-0845-4
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : https://hdl.handle.net/2066/79562   https://hdl.handle.net/2066/79562

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Subject: NCEBP 2: Evaluation of complex medical interventions
ONCOL 2: Age-related aspects of cancer
ONCOL 3: Translational research
ONCOL 4: Quality of Care
ONCOL 5: Aetiology, screening and detection
Organization: Medical Oncology
Orthopaedics
Pathology
Radiology
Journal title:
Virchows Archiv
Volume: vol. 455
Issue: iss. 5
Page start: p. 455
Page end: p. 459
Abstract:
Aneurysmal bone cysts (ABCs) are benign bone tumors consisting of blood-filled cavities lined by connective tissue septa. Recently, the hypothesis that ABCs are lesions reactive to local hemodynamics has been challenged after the discovery of specific recurrent chromosomal abnormalities. Multiple cases of malignant transformation of ABC into (osteo)sarcoma have been described, as well as a number of cases of telangiectatic osteosarcoma which had been misdiagnosed as ABC. We herewith document a case of a pelvic ABC metastatic to the lung, liver, and kidneys. Diagnosis was confirmed by the presence of a break in the USP6 gene, which is pathognomonic for ABC, in a pulmonary metastasis of our patient. Sarcomatous transformation as an explanation for this behavior was ruled out by demonstrating diploid DNA content in both the pulmonary lesion and the primary tumor.

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