The shortest path to cardiac activation.
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Publication year
2010Author(s)
Publisher
S.l. : s.n.
ISBN
9789090246031
Number of pages
119 p.
Annotation
RU Radboud Universiteit Nijmegen, 05 februari 2010
Promotor : Oosterom, A. van Co-promotor : Oostendorp, T.F.
Publication type
Dissertation
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Organization
Cognitive Neuroscience
Former Organization
Medical Physics and Biophysics
Subject
DCN 1: Perception and ActionAbstract
This thesis describes the application of the shortest path algorithm in the simulation of cardiac activation.
This method is both used in the forward simulation of an electrocardiogram (ECG) as well as in the non-invasive imaging of cardiac activation and recovery.
Due to the immense number of cardiac cells a source model is required to simulate the electrical cardiac generator. The source model used in this thesis is the equivalent double layer source model. One of the major
advantages of this model is the close relation with electrophysiological characteristics of the cardiac cells.
This enables the introduction of electrophysiological knowledge in the require initial estimate on behalf of the non-invasive imaging method. Knowledge on the propagation of activation within the myocardial tissue was introduced to generate realistic activation patterns, both for the atria and the ventricles.
The inverse procedure described in this thesis proves to be robust, both in respect to the number of leads
used and to the waveform parameterization used in the source model. The robustness is mainly attributed to the
high quality of the initial activation estimate based on the dedicated implementation of the shortest path
algorithm, the fastest route algorithm. This results in an initial estimate that is close to the actual
activation and recovery times, which minimize the risk that the subsequently applied inverse procedure ends
up in an unrealistic local minimum in the parameter space.
The clinical application of this inverse procedure is now coming within reach. Selecting the optimal lead
system might enable the inverse procedure to be executed by using a limited number of leads (15-30). For
specific cases and research applications, like shown for the Brugada patient, the proposed non-invasive
imaging method seems to have reached maturity.
This item appears in the following Collection(s)
- Academic publications [245396]
- Dissertations [13780]
- Electronic publications [132943]
- Faculty of Medical Sciences [93203]
- Open Access publications [106466]
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