Peripheral and central neurologic complications in type 2 diabetes mellitus: No association in individual patients
Publication year
2008Author(s)
Number of pages
6 p.
Source
Journal of the Neurological Sciences, 264, 1-2, (2008), pp. 157-162ISSN
Publication type
Article / Letter to editor

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Organization
SW OZ DCC NRP
Medical Psychology
Geriatrics
Journal title
Journal of the Neurological Sciences
Volume
vol. 264
Issue
iss. 1-2
Languages used
English (eng)
Page start
p. 157
Page end
p. 162
Subject
DCN 1: Perception and Action; DCN 2: Functional Neurogenomics; DI-BCB_DCC_Theme 3: Plasticity and Memory; EBP 1: Determinants of Health and Disease; EBP 2: Effective Hospital Care; NCEBP 11: Alzheimer Centre; NCEBP 8: Psychological determinants of chronic illness; Neuropsychology and rehabilitation psychology; UMCN 3.2: Cognitive neurosciences; Neuro- en revalidatiepsychologieAbstract
Diabetes mellitus is associated with end-organ complications in the peripheral and central nervous system. It is unknown if these complications share a common aetiology, and if they co-occur in the same patient. The aim of the present study was to relate different measures of peripheral neuropathy in patients with type 2 diabetes mellitus (DM2) to cognition and brain MRI. A standardized neurological examination and questionnaire, neuropsychological examination and brain MRI were performed in 122 patients with DM2 and 56 matched controls. Measures of peripheral neuropathy were vibration threshold, a sensory examination sum score and the Toronto Clinical Neuropathy Scoring System. Neuropsychological test scores were expressed in standardized z-values across five predetermined cognitive domains. White matter lesions and cortical and subcortical atrophy were rated on MRI. Overall 38% of the patients with DM2 and 12% of the controls were classified as having any neuropathy (p<0.001). Patients with DM2 had a lower performance on the neuropsychological tests, more white matter lesions (p<0.01) and more atrophy (p<0.01) than controls. Within the DM2 group none of the measures of peripheral neuropathy was related to MRI abnormalities or cognitive dysfunction (linear regression analyses, adjusted for age, education, sex). We conclude that peripheral neuropathy in patients with DM2 is not related to cognitive dysfunction and brain abnormalities. This indicates that central and peripheral neurological complications of DM2 might have different etiologies.
This item appears in the following Collection(s)
- Academic publications [227881]
- Faculty of Medical Sciences [86219]
- Faculty of Social Sciences [28470]
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