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Publication year
2008Source
Netherlands Heart Journal, 16, 12, (2008), pp. 406-11ISSN
Publication type
Article / Letter to editor

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Organization
Cardiology
Journal title
Netherlands Heart Journal
Volume
vol. 16
Issue
iss. 12
Page start
p. 406
Page end
p. 11
Subject
NCEBP 14: Cardiovascular diseases; UMCN 2.1: Heart, lung and circulationAbstract
Pregnancy in women with mechanical valve prostheses has a high maternal complication rate including valve thrombosis and death. Coumarin derivatives are relatively safe for the mother with a lower incidence of valve thrombosis than un-fractionated and low-molecular-weight heparin, but carry the risk of embryopathy, which is probably dose-dependent. The different anticoagulation regimens are discussed in this review. When valve thrombosis occurs during pregnancy, thrombolysis is the preferable therapeutic option. Bioprostheses have a more favourable pregnancy outcome than mechanical prostheses but due to the high re-operation rate in young women they do not constitute the ideal alternative. When women with native valve stenosis need pre-pregnancy intervention, mitral balloon valvuloplasty is the best option in mitral stenosis, while the Ross operation or homograft implantation may be the preferable surgical regimen in aortic stenosis. (Neth Heart J 2008;16:406-11.).
This item appears in the following Collection(s)
- Academic publications [234419]
- Electronic publications [117392]
- Faculty of Medical Sciences [89250]
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