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Title: Pregnancy in women with prosthetic heart valves.
Author(s): Pieper, P.G.; Balci, A.; Dijk, A.P.J. van
Publication year: 2008
Source: Netherlands Heart Journal, vol. 16, iss. 12, (2008), pp. 406-411
ISSN: 1568-5888
DOI: https://doi.org/10.1007/BF03086187
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/71380   http://hdl.handle.net/2066/71380

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Subject: NCEBP 14: Cardiovascular diseases
UMCN 2.1: Heart, lung and circulation
Organization: Cardiology
Journal title:
Netherlands Heart Journal
Volume: vol. 16
Issue: iss. 12
Page start: p. 406
Page end: p. 411
Abstract:
Pregnancy in women with mechanical valve prostheses has a high maternal complication rate including valve thrombosis and death. Coumarin derivatives are relatively safe for the mother with a lower incidence of valve thrombosis than un-fractionated and low-molecular-weight heparin, but carry the risk of embryopathy, which is probably dose-dependent. The different anticoagulation regimens are discussed in this review. When valve thrombosis occurs during pregnancy, thrombolysis is the preferable therapeutic option. Bioprostheses have a more favourable pregnancy outcome than mechanical prostheses but due to the high re-operation rate in young women they do not constitute the ideal alternative. When women with native valve stenosis need pre-pregnancy intervention, mitral balloon valvuloplasty is the best option in mitral stenosis, while the Ross operation or homograft implantation may be the preferable surgical regimen in aortic stenosis. (Neth Heart J 2008;16:406-11.).

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