Confirmation of dyslexia susceptibility loci on chromosomes 1p and 2p, but not 6p in a Dutch sib-pair collection.

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Publication year
2008Source
American Journal of Medical Genetics. Part B : Neuropsychiatric Genetics, 147, 3, (2008), pp. 294-300ISSN
Publication type
Article / Letter to editor

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Organization
Human Genetics
Psychiatry
Medical Psychology
Neurology
Journal title
American Journal of Medical Genetics. Part B : Neuropsychiatric Genetics
Volume
vol. 147
Issue
iss. 3
Page start
p. 294
Page end
p. 300
Subject
DCN 1: Perception and Action; DCN 2: Functional Neurogenomics; IGMD 3: Genomic disorders and inherited multi-system disorders; NCEBP 8: Psychological determinants of chronic illness; NCMLS 1: Immunity, infection and tissue repair; NCMLS 6: Genetics and epigenetic pathways of disease; UMCN 3.1: Neuromuscular development and genetic disorders; UMCN 3.2: Cognitive neurosciences; UMCN 5.1: Genetic defects of metabolismAbstract
In this study, we attempted to confirm genetic linkage to developmental dyslexia and reading-related quantitative traits of loci that have been shown to be associated with dyslexia in previous studies. In our sample of 108 Dutch nuclear families, the categorical trait showed strongest linkage to 1p36 (NPL-LOD = 2.1). LOD scores for quantitative traits word-reading, non-word reading, and rapid naming peaked near the same location as the categorical trait, as well as on chromosome 2. Non-word repetition showed little phenotypic correlation with dyslexia or with the other quantitative traits, and this trait showed linkage peaks on 11p and 15q. No evidence for linkage to 6p22-23 was found for this set of families. Comparison of our results and literature data shows that loci link to different phenotypes in different samples. The mutual connections of these traits and their relation to developmental dyslexia remain elusive.
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- Academic publications [234412]
- Electronic publications [117392]
- Faculty of Medical Sciences [89250]
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