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Title: Confirmation of dyslexia susceptibility loci on chromosomes 1p and 2p, but not 6p in a Dutch sib-pair collection.
Author(s): Kovel, C.G.F. de; Franke, B. ; Hol, F.A. ; Lebrec, J.J.; Maassen, B.A.M. ; Brunner, H.G. ; Padberg, G.W.A.M. ; Platko, J.; Pauls, D.
Publication year: 2008
Source: American Journal of Medical Genetics. Part B : Neuropsychiatric Genetics, vol. 147, iss. 3, (2008), pp. 294-300
ISSN: 1552-4841
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/71322   http://hdl.handle.net/2066/71322

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Subject: DCN 1: Perception and Action
DCN 2: Functional Neurogenomics
IGMD 3: Genomic disorders and inherited multi-system disorders
NCEBP 8: Psychological determinants of chronic illness
NCMLS 1: Immunity, infection and tissue repair
NCMLS 6: Genetics and epigenetic pathways of disease
UMCN 3.1: Neuromuscular development and genetic disorders
UMCN 3.2: Cognitive neurosciences
UMCN 5.1: Genetic defects of metabolism
Organization: Human Genetics
Psychiatry
Medical Psychology
Neurology
Journal title:
American Journal of Medical Genetics. Part B : Neuropsychiatric Genetics
Volume: vol. 147
Issue: iss. 3
Page start: p. 294
Page end: p. 300
Abstract:
In this study, we attempted to confirm genetic linkage to developmental dyslexia and reading-related quantitative traits of loci that have been shown to be associated with dyslexia in previous studies. In our sample of 108 Dutch nuclear families, the categorical trait showed strongest linkage to 1p36 (NPL-LOD = 2.1). LOD scores for quantitative traits word-reading, non-word reading, and rapid naming peaked near the same location as the categorical trait, as well as on chromosome 2. Non-word repetition showed little phenotypic correlation with dyslexia or with the other quantitative traits, and this trait showed linkage peaks on 11p and 15q. No evidence for linkage to 6p22-23 was found for this set of families. Comparison of our results and literature data shows that loci link to different phenotypes in different samples. The mutual connections of these traits and their relation to developmental dyslexia remain elusive.

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