Psoriasis is associated with increased beta-defensin genomic copy number.
until further notice
SourceNature Genetics, 40, 1, (2008), pp. 23-25
Article / Letter to editor
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Epidemiology, Biostatistics & HTA
SubjectEBP 1: Determinants in Health and Disease; IGMD 5: Health aging / healthy living; IGMD 6: Hormonal regulation; N4i 1: Pathogenesis and modulation of inflammation; N4i 4: Auto-immunity, transplantation and immunotherapy; NCEBP 14: Cardiovascular diseases; NCEBP 1: Molecular epidemiology; NCMLS 1: Immunity, infection and tissue repair; NCMLS 1: Infection and autoimmunity; ONCOL 3: Translational research; UMCN 4.2: Chronic inflammation and autoimmunity; UMCN 5.2: Endocrinology and reproduction
Psoriasis is a common inflammatory skin disease with a strong genetic component. We analyzed the genomic copy number polymorphism of the beta-defensin region on human chromosome 8 in 179 Dutch individuals with psoriasis and 272 controls and in 319 German individuals with psoriasis and 305 controls. Comparisons in both cohorts showed a significant association between higher genomic copy number for beta-defensin genes and risk of psoriasis.
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