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Title: Objective and perspective determine the choice of composite endpoint.
Author(s): Borm, G.F. ; Teerenstra, S. ; Zielhuis, G.A.
Publication year: 2008
Source: Journal of Clinical Epidemiology, vol. 61, iss. 2, (2008), pp. 99-101
ISSN: 0895-4356
DOI: http://dx.doi.org/10.1016/j.jclinepi.2007.10.001
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/71246   http://hdl.handle.net/2066/71246

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Subject: NCEBP 12: Human Reproduction
NCEBP 2: Evaluation of complex medical interventions
ONCOL 2: Age-related aspects of cancer
UMCN 1.5: Interventional oncology
Organization: IQ Healthcare
Health Evidence
Former Organization: Epidemiology, Biostatistics & HTA
Journal title:
Journal of Clinical Epidemiology
Volume: vol. 61
Issue: iss. 2
Page start: p. 99
Page end: p. 101
Abstract:
The most important consideration in the choice of study design and endpoint is that these two features match and represent the objective and the perspective of the trial as closely as possible. The mechanism may also be helpful, but arguments based on the mechanism, structure or levels of the variables, or based on practical considerations, such as (statistical) efficiency, must always be secondary considerations.

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