Conservation of divergent transcription in fungi.
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SourceTrends in Genetics, 24, 5, (2008), pp. 207-211
Article / Letter to editor
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Trends in Genetics
SubjectIGMD 8: Mitochondrial medicine; NCMLS 2: Metabolism, transport and motion; NCMLS 4: Energy and redox metabolism; UMCN 5.3: Cellular energy metabolism; NCMLS 2: Metabolism, transport and motion
The comparison of fully sequenced genomes enables the study of selective constraints that determine genome organisation. We show that, in fungi, adjacent divergently transcribed (<---->) genes are more conserved in orientation than convergent (--><--) or co-oriented (-->-->) gene pairs. Furthermore, the time divergent orientation of two genes is conserved correlates with the degree of their co-expression and with the likelihood of them being functionally related. The functional interactions of the proteins encoded by the conserved divergent gene pairs indicate a potential for protein function prediction in eukaryotes.
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