Semaphorin 3E expression correlates inversely with Plexin D1 during tumor progression.
Publication year
2008Source
American Journal of Pathology, 173, 6, (2008), pp. 1873-1881ISSN
Publication type
Article / Letter to editor

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Organization
Pathology
Journal title
American Journal of Pathology
Volume
vol. 173
Issue
iss. 6
Page start
p. 1873
Page end
p. 1881
Subject
NCMLS 1: Immunity, infection and tissue repair; NCMLS 7: Chemical and physical biology; UMCN 1.3: Tumor microenvironmentAbstract
Plexin D1 (PLXND1) is broadly expressed on tumor vessels and tumor cells in a number of different human tumor types. Little is known, however, about the potential functional contribution of PLXND1 expression to tumor development. Expression of semaphorin 3E (Sema3E), one of the ligands for PLXND1, has previously been correlated with invasive behavior and metastasis, suggesting that the PLXND1-Sema3E interaction may play a role in tumor progression. Here we investigated PLXND1 and Sema3E expression during tumor progression in cases of melanoma. PLXND1 was not expressed by melanocytic cells in either naevi or melanomas in situ, whereas expression increased with invasion level, according to Clark's criteria. Furthermore, 89% of the metastatic melanomas examined showed membranous PLXND1-staining of tumor cells. Surprisingly, expression of Sema3E was inversely correlated with tumor progression, with no detectable staining in melanoma metastasis. To functionally assess the effects of Sema3E expression on tumor development, we overexpressed Sema3E in a xenograft model of metastatic melanoma. Sema3E expression dramatically decreased metastatic potential. These results show that PLXND1 expression during tumor development is strongly correlated with both invasive behavior and metastasis, but exclude Sema3E as an activating ligand.
This item appears in the following Collection(s)
- Academic publications [204994]
- Electronic publications [103259]
- Faculty of Medical Sciences [81051]
- Open Access publications [71791]
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