Severe fatigue and related factors in cancer patients before the initiation of treatment.
until further notice
SourceBritish Journal of Cancer, 99, 9, (2008), pp. 1408-1414
Article / Letter to editor
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British Journal of Cancer
SubjectEBP 3: Effective Primary Care and Public Health; NCEBP 10: Human Movement & Fatigue; NCEBP 7: Effective primary care and public health; NCEBP 8: Psychological determinants of chronic illness; ONCOL 4: Quality of Care; UMCN 1.5: Interventional oncology; NCEBP 10: Human Movement & Fatigue; NCEBP 8: Psychological determinants of chronic illness
It is generally known that fatigue is a common symptom during cancer treatment, and in cancer survivors. However, fatigue was never studied after diagnosis, before cancer treatment was initiated. This study investigated the prevalence of severe fatigue, and related factors, in cancer patients before the initiation of treatment. One hundred and seventy-nine patients with various malignancies were assessed before start of treatment with curative intention, including the Checklist Individual Strength, Sickness Impact Profile, Beck Depression Inventory Primary Care, Symptom Checklist-90, and six Numeric Rating Scales to measure fatigue, pain and physical activity. To test which factors contributed to severe fatigue a logistic regression analysis was performed. In total 23.5% patients were severely fatigued, varying between diagnoses; prostate cancer (14.3%), breast cancer (20.3%), and gastrointestinal cancer (28.1%). Currently lower physical activity (P=0.013), more depressive mood (P=0.014), impaired sleep and rest during the day and night (P=0.045), and fatigue 1 year before diagnosis (P=0.005) contributed to severe fatigue. Relatively large numbers of cancer patients already experience severe fatigue before initiation of treatment, varying between 14-28%. The factors that contributed to severe fatigue at this stage were physical activity, depressive mood, impaired sleep and rest, and fatigue 1 year before diagnosis.
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