
Fulltext:
71048.pdf
Embargo:
until further notice
Size:
1.629Mb
Format:
PDF
Description:
publisher's version
Publication year
2008Source
Trends in Cognitive Sciences, 12, 1, (2008), pp. 31-40ISSN
Publication type
Article / Letter to editor

Display more detailsDisplay less details
Organization
Psychiatry
Journal title
Trends in Cognitive Sciences
Volume
vol. 12
Issue
iss. 1
Page start
p. 31
Page end
p. 40
Subject
DCN 1: Perception and Action; UMCN 3.2: Cognitive neurosciencesAbstract
5-Hydroxytryptamine (5-HT, serotonin) has long been implicated in a wide variety of emotional, cognitive and behavioural control processes. However, its precise contribution is still not well understood. Depletion of 5-HT enhances behavioural and brain responsiveness to punishment or other aversive signals, while disinhibiting previously rewarded but now punished behaviours. Findings suggest that 5-HT modulates the impact of punishment-related signals on learning and emotion (aversion), but also promotes response inhibition. Exaggerated aversive processing and deficient response inhibition could underlie distinct symptoms of a range of affective disorders, namely stress- or threat-vulnerability and compulsive behaviour, respectively. We review evidence from studies with human volunteers and experimental animals that begins to elucidate the neurobiological systems underlying these different effects.
This item appears in the following Collection(s)
- Academic publications [227881]
- Electronic publications [107344]
- Faculty of Medical Sciences [86219]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.