Serotoninergic regulation of emotional and behavioural control processes.
until further notice
SourceTrends in Cognitive Sciences, 12, 1, (2008), pp. 31-40
Article / Letter to editor
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Trends in Cognitive Sciences
SubjectDCN 1: Perception and Action; UMCN 3.2: Cognitive neurosciences
5-Hydroxytryptamine (5-HT, serotonin) has long been implicated in a wide variety of emotional, cognitive and behavioural control processes. However, its precise contribution is still not well understood. Depletion of 5-HT enhances behavioural and brain responsiveness to punishment or other aversive signals, while disinhibiting previously rewarded but now punished behaviours. Findings suggest that 5-HT modulates the impact of punishment-related signals on learning and emotion (aversion), but also promotes response inhibition. Exaggerated aversive processing and deficient response inhibition could underlie distinct symptoms of a range of affective disorders, namely stress- or threat-vulnerability and compulsive behaviour, respectively. We review evidence from studies with human volunteers and experimental animals that begins to elucidate the neurobiological systems underlying these different effects.
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