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Title: Serotoninergic regulation of emotional and behavioural control processes.
Author(s): Cools, R. ; Roberts, A.C.; Robbins, T.W.
Publication year: 2008
Source: Trends in Cognitive Sciences, vol. 12, iss. 1, (2008), pp. 31-40
ISSN: 1364-6613
DOI: https://doi.org/10.1016/j.tics.2007.10.011
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/71048   http://hdl.handle.net/2066/71048

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Subject: DCN 1: Perception and Action
UMCN 3.2: Cognitive neurosciences
Organization: Psychiatry
Journal title:
Trends in Cognitive Sciences
Volume: vol. 12
Issue: iss. 1
Page start: p. 31
Page end: p. 40
Abstract:
5-Hydroxytryptamine (5-HT, serotonin) has long been implicated in a wide variety of emotional, cognitive and behavioural control processes. However, its precise contribution is still not well understood. Depletion of 5-HT enhances behavioural and brain responsiveness to punishment or other aversive signals, while disinhibiting previously rewarded but now punished behaviours. Findings suggest that 5-HT modulates the impact of punishment-related signals on learning and emotion (aversion), but also promotes response inhibition. Exaggerated aversive processing and deficient response inhibition could underlie distinct symptoms of a range of affective disorders, namely stress- or threat-vulnerability and compulsive behaviour, respectively. We review evidence from studies with human volunteers and experimental animals that begins to elucidate the neurobiological systems underlying these different effects.

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