Neural correlates of strategic memory retrieval: differentiating between spatial-associative and temporal-associative strategies.
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SourceHuman Brain Mapping, 29, 9, (2008), pp. 1068-1079
Article / Letter to editor
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Donders Centre for Cognitive Neuroimaging
F.C. Donders Centre for Cognitive Neuroimaging
Medical Physics and Biophysics
Human Brain Mapping
Subject110 000 Neurocognition of Language; 130 000 Cognitive Neurology & Memory; DCN 2: Functional Neurogenomics; DCN 3: Neuroinformatics; EBP 1: Determinants of Health and Disease; NCEBP 8: Psychological determinants of chronic illness; UMCN 3.2: Cognitive neurosciences; EBP 1: Determinants of Health and Disease
Remembering complex, multidimensional information typically requires strategic memory retrieval, during which information is structured, for instance by spatial- or temporal associations. Although brain regions involved in strategic memory retrieval in general have been identified, differences in retrieval operations related to distinct retrieval strategies are not well-understood. Thus, our aim was to identify brain regions whose activity is differentially involved in spatial-associative and temporal-associative retrieval. First, we showed that our behavioral paradigm probing memory for a set of object-location associations promoted the use of a spatial-associative structure following an encoding condition that provided multiple associations to neighboring objects (spatial-associative condition) and the use of a temporal-associative structure following another study condition that provided predominantly temporal associations between sequentially presented items (temporal-associative condition). Next, we used an adapted version of this paradigm for functional MRI, where we contrasted brain activity related to the recall of object-location associations that were either encoded in the spatial- or the temporal-associative condition. In addition to brain regions generally involved in recall, we found that activity in higher-order visual regions, including the fusiform gyrus, the lingual gyrus, and the cuneus, was relatively enhanced when subjects used a spatial-associative structure for retrieval. In contrast, activity in the globus pallidus and the thalamus was relatively enhanced when subjects used a temporal-associative structure for retrieval. In conclusion, we provide evidence for differential involvement of these brain regions related to different types of strategic memory retrieval and the neural structures described play a role in either spatial-associative or temporal-associative memory retrieval.
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