The effect of hyperbaric oxygen therapy on quality of life in oral and oropharyngeal cancer patients treated with radiotherapy.
until further notice
SourceInternational Journal of Oral and Maxillofacial Surgery, 37, 3, (2008), pp. 255-259
Article / Letter to editor
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Oral and Maxillofacial Surgery
Religie- en cultuurtheorie
International Journal of Oral and Maxillofacial Surgery
SubjectNCEBP 2: Evaluation of complex medical interventions; ONCOL 3: Translational research; UMCN 1.1: Functional Imaging; UMCN 1.5: Interventional oncology
Radiotherapy is used in the setting of curative treatment for head and neck cancer. Xerostomia and related problems occur when major salivary glands are included in the irradiation fields. This reduces quality of life (QOL). Hyperbaric oxygen therapy (HBOT) is a well accepted treatment or prevention modality for osteoradionecrosis of the jawbones and soft-tissue necrosis. It is unknown if and to what extent HBOT influences xerostomia and xerostomia-related QOL. To address this, a prospective study was conducted. Twenty-one patients who underwent radiotherapy for an oral or oropharyngeal carcinoma completed a European Organization for Research and Treatment of Cancer QOL questionnaire before HBOT, as part of the treatment/prevention of osteoradionecrosis, and 1 and 2 years after HBOT. Swallowing-related problems significantly decreased in time, and there was a reported subjective increase in saliva quantity and an improvement in sense of taste. The results suggest that HBOT may positively influence these long-term radiotherapy sequelae.
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