The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane.
until further notice
SourceKidney International. Supplement, 73, 2, (2008), pp. 220-5
Article / Letter to editor
Display more detailsDisplay less details
IMM - Institute for Molecules and Materials
Kidney International. Supplement
SubjectIGMD 9: Renal disorder; NCMLS 2: Metabolism, transport and motion; NCMLS 5: Membrane transport and intracellular motility; Synthetic Organic Chemistry; UMCN 5.4: Renal disorders
The Breast Cancer Resistance Protein (BCRP/ABCG2) is a transporter restricting absorption and enhancing excretion of many compounds including anticancer drugs. This transporter is highly expressed in many tissues; however, in human kidney, only the mRNA was found in contrast to the mouse kidney, where the transporter is abundant. In bcrp/abcg2((-/-)) mice, the expression of two sterol transporter genes, abcg5 and abcg8, was strongly increased in the kidney, perhaps as a compensatory mechanism to upregulate efflux. We found using immunohistochemical analysis clear localization of BCRP/ABCG2 to the proximal tubule brush border membrane of the human kidney comparable to that of other ABC transporters such as P-glycoprotein/ABCB1, MRP2/ABCC2, and MRP4/ABCC4. Hoechst 33342 dye efflux from primary human proximal tubule cells was significantly reduced by the BCRP/ABCG2 inhibitors fumitremorgin C and nelfinavir. Our study shows that in addition to other apical ABC transporters, BCRP/ABCG2 may be important in renal drug excretion.
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.