The role of biomarkers in the early detection of anthracycline-induced cardiotoxicity in children: a review of the literature.
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Publication year
2008Source
Pediatric Hematology and Oncology, 25, 7, (2008), pp. 655-64ISSN
Publication type
Article / Letter to editor
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Organization
Paediatrics - OUD tm 2017
Journal title
Pediatric Hematology and Oncology
Volume
vol. 25
Issue
iss. 7
Page start
p. 655
Page end
p. 64
Subject
IGMD 1: Functional imaging; NCEBP 14: Cardiovascular diseases; ONCOL 2: Age-related aspects of cancer; UMCN 1.4: Immunotherapy, gene therapy and transplantation; UMCN 5.5: Nutrition and HealthAbstract
Anthracycline-induced cardiotoxicity can cause serious health problems for an increasing number of children surviving childhood malignancies. Early detection of cardiac failure is critically important for the prevention and management of anthracycline-induced cardiotoxicity. The aim of this research was to determine the role of biomarkers in the early detection of anthracycline-induced cardiotoxicity in children. A literature review is presented of studies regarding the use of the biomarkers B-type natriuretic peptide (BNP), N-terminal pro-BNP (NT-pro-BNP), cardiac troponin T (cTnT), and cardiac troponin I (cTnI) in relation with anthracycline-induced cardiotoxicity in children. Six of 14 studies in children showed a significant relation between elevated biomarkers BNP, NT-pro-BNP, and cTnT and cardiac dysfunction. Six studies, although small, suggest that BNP, NT-pro-BNP, and cTnT might be useful markers in the early detection of anthracycline-induced cardiotoxicity.
This item appears in the following Collection(s)
- Academic publications [238441]
- Electronic publications [122523]
- Faculty of Medical Sciences [90373]
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