Dynamics of human respiratory virus-specific CD8+ T cell responses in blood and airways during episodes of common cold.

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Publication year
2008Source
Journal of Immunology, 181, 8, (2008), pp. 5551-5559ISSN
Publication type
Article / Letter to editor

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Organization
Tumorimmunology
Paediatrics
Journal title
Journal of Immunology
Volume
vol. 181
Issue
iss. 8
Page start
p. 5551
Page end
p. 5559
Subject
NCMLS 1: Immunity, infection and tissue repairAbstract
We determined the dynamics of CD8(+) T cells specific for influenza virus and respiratory syncytial virus in blood and tracheostoma aspirates of children during the course of respiratory infections. We showed that during localized respiratory infections the ratio of activated effector CD8(+) T cells to resting memory/naive CD8(+) T cells in peripheral blood increased significantly. Furthermore, the number of effector/memory T cells specific for respiratory viruses declined in blood and increased in the airways, suggesting that these T cells redistributed from blood to airways. T cells specific for the infecting virus were present in the airways for longer periods at increased levels than nonspecifically recruited bystander T cells. After clearance of the infection, the ratio of resting memory and naive CD8(+) T cells normalized in peripheral blood and also memory T cell numbers specific for unrelated viruses that declined during the infection due to bystander recruitment were restored. Taken together, these results showed a significant systemic T cell response during relatively mild secondary infections and extensive dynamics of virus-specific and nonspecific Ag-experienced T cells.
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- Academic publications [205106]
- Electronic publications [103308]
- Faculty of Medical Sciences [81055]
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