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Publication year
2008Source
American Journal of Orthodontics and Dentofacial Orthopedics, 133, 5, (2008), pp. 752-7ISSN
Publication type
Article / Letter to editor

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Organization
Orthodontics and Oral Biology
Dentistry
Journal title
American Journal of Orthodontics and Dentofacial Orthopedics
Volume
vol. 133
Issue
iss. 5
Page start
p. 752
Page end
p. 7
Subject
NCEBP 2: Evaluation of complex medical interventions; NCMLS 1: Immunity, infection and tissue repairAbstract
INTRODUCTION: Age effects on orthodontically induced periodontal vascular reactions have not been studied. The aim of the present study was to test the hypothesis that prolonged tooth movement induces age-related increases in periodontal vascularity. METHODS: A standardized orthodontic appliance was placed in 2 groups of 30 rats aged 6 weeks and 9 to 12 months. At 1, 2, 4, 8, and 12 weeks, animals were killed. Blood vessels (BV) were identified based on their morphology and by immunohistochemical staining for alpha-smooth muscle actin. At each study region, surface areas (SA) of the periodontal ligament space and each BV were measured; BV mean SA, BV relative SA (the summed BV SA as a percentage of the periodontal ligament SA), and BV numbers were calculated. RESULTS: Pressure and tension regions showed similar vascular changes. Young rats had lower BV relative SA and BV mean SA in the early phase of force application (< 4 weeks); this increased in the late phase, reaching the same level as adult rats. In the late phase (4-12 weeks), young rats had increases of both small- and large-sized BV that did not affect the BV mean SA; adult rats had an increase of small-sized BV only; this resulted in decreased BV mean SA. CONCLUSIONS: The hypothesis was confirmed that prolonged tooth movement increases periodontal vascularity, which is age related. These results suggest that clinicians should consider age-related difference in tissue reactions during orthodontic tooth movement.
This item appears in the following Collection(s)
- Academic publications [232165]
- Electronic publications [115400]
- Faculty of Medical Sciences [89075]
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