Growth hormone producing prolactinoma in juvenile cystinosis: a simple coincidence?
until further notice
SourcePediatric Nephrology, 23, 2, (2008), pp. 307-10
Article / Letter to editor
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Paediatrics - OUD tm 2017
SubjectIGMD 5: Health aging / healthy living; IGMD 8: Mitochondrial medicine; UMCN 3.2: Cognitive neurosciences; UMCN 5.2: Endocrinology and reproduction
Juvenile cystinosis was diagnosed in a patient who presented with severe headache attacks and photophobia. Treatment with oral cysteamine and topical cysteamine eye drops was started. One-and-a-half years later, he developed unilateral gynecomastia and elevated prolactin and growth hormone levels. A pituitary macroprolactinoma was discovered and successfully treated with the dopamine agonist cabergoline. Increased serum growth hormone levels were attributed to enhanced growth hormone production by the prolactinoma and somatostatin inhibition by cysteamine. Although the occurrence of prolactinoma in this patient could be a simple coincidence, it might also be a rare yet unrecognised complication of cystinosis.
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