Subject:
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N4i 1: Pathogenesis and modulation of inflammation N4i 2: Invasive mycoses and compromised host NCMLS 1: Immunity, infection and tissue repair NCMLS 1: Infection and autoimmunity UMCN 4.1: Microbial pathogenesis and host defense |
Journal title:
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Current Opinion in Microbiology
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Abstract:
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The recognition of fungi is mediated by germline pattern recognition receptors (PRRs) such as Toll-like receptors and lectin receptors that interact with conserved structures of the microorganisms, the pathogen-associated molecular patterns (PAMPs). Subsequently, PRRs activate intracellular signals that collaborate for the efficient activation of the host defense. The specificity of these responses is achieved through the activation of a particular mosaic of PRRs, that is determined by the available fungal PAMPs and the innate immune cells involved. This will determine a divergence of the final type of reaction, and in this way the innate host defense has the capability to deliver tailored responses to each pathogen.
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