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Title: Host-microbe interactions: innate pattern recognition of fungal pathogens.
Author(s): Veerdonk, F.L. van de ; Kullberg, B.J. ; Meer, J.W.M. van der ; Gow, N.A.; Netea, M.G.
Publication year: 2008
Source: Current Opinion in Microbiology, vol. 11, iss. 4, (2008), pp. 305-312
ISSN: 1369-5274
DOI: http://dx.doi.org/10.1016/j.mib.2008.06.002
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/69982   http://hdl.handle.net/2066/69982

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Subject: N4i 1: Pathogenesis and modulation of inflammation
N4i 2: Invasive mycoses and compromised host
NCMLS 1: Immunity, infection and tissue repair
NCMLS 1: Infection and autoimmunity
UMCN 4.1: Microbial pathogenesis and host defense
Organization: Internal Medicine
Journal title:
Current Opinion in Microbiology
Volume: vol. 11
Issue: iss. 4
Page start: p. 305
Page end: p. 312
Abstract:
The recognition of fungi is mediated by germline pattern recognition receptors (PRRs) such as Toll-like receptors and lectin receptors that interact with conserved structures of the microorganisms, the pathogen-associated molecular patterns (PAMPs). Subsequently, PRRs activate intracellular signals that collaborate for the efficient activation of the host defense. The specificity of these responses is achieved through the activation of a particular mosaic of PRRs, that is determined by the available fungal PAMPs and the innate immune cells involved. This will determine a divergence of the final type of reaction, and in this way the innate host defense has the capability to deliver tailored responses to each pathogen.

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