Human platelets attenuate Aspergillus species via granule-dependent mechanisms.
until further notice
SourceThe Journal of Infectious Diseases, 198, 8, (2008), pp. 1243-6
Article / Letter to editor
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The Journal of Infectious Diseases
SubjectN4i 2: Invasive mycoses and compromised host; UMCN 1.2: Molecular diagnosis, prognosis and monitoring; UMCN 4.2: Chronic inflammation and autoimmunity
Using laser scanning microscopy, we investigated whether platelets are capable of internalizing Aspergillus conidia and examined Aspergillus-platelet adherence. The influence of platelets on fungal growth was evaluated by assessing galactomannan (GM) release, hyphal elongation, and colony size. A secretion assay with [(3)H]-serotonin (5-hydroxytryptamine [5-HT]) was performed. Exposure to platelets resulted in significantly decreased GM release (p<.05), hyphal elongation (p<.001), colony size, pigmentation, and 5-HT release ( p<.05). A lack of antifungal effects was observed with the microfilament inhibitor cytochalasin D. Platelets attenuate the virulence of Aspergillus species in vitro on the basis of granule-dependent effects.
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