Aspergillus calidoustus sp. nov., causative agent of human infections previously assigned to Aspergillus ustus.
Publication year
2008Source
Eukaryotic Cell, 7, 4, (2008), pp. 630-638ISSN
Publication type
Article / Letter to editor

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Organization
Medical Microbiology
Journal title
Eukaryotic Cell
Volume
vol. 7
Issue
iss. 4
Page start
p. 630
Page end
p. 638
Subject
N4i 2: Invasive mycoses and compromised host; NCMLS 1: Immunity, infection and tissue repair; NCMLS 1: Infection and autoimmunity; UMCN 4.1: Microbial pathogenesis and host defenseAbstract
Aspergillus ustus is a relatively rare human pathogen causing invasive infections in immunocompromised hosts. In this study isolates originating from clinical and other sources have been examined using molecular, morphological, and physiological approaches to clarify their species assignment. Phylogenetic analysis of partial beta-tubulin, calmodulin, actin, and intergenic transcribed spacer sequences indicated that none of the clinical isolates recognized previously as A. ustus belongs to this species. All but two of these isolates formed a well-defined clade related to A. pseudodeflectus based on sequence analysis of protein-coding regions. Morphological and physiological examination of these isolates indicated that they are able to grow above 37 degrees C, in contrast with A. ustus isolates, and give a positive Ehrlich reaction, in contrast with related species including A. granulosus, A. ustus, and A. pseudodeflectus. These isolates are proposed as a new species, A. calidoustus. Antifungal susceptibility testing showed that this species has decreased susceptibilities to several antifungal drugs. The triazoles are inactive in vitro, including the new azole posaconazole.
This item appears in the following Collection(s)
- Academic publications [204968]
- Faculty of Medical Sciences [81049]
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