Antineuronal antibodies in Parkinson's disease.
Fulltext:
69841.pdf
Embargo:
until further notice
Size:
71.58Kb
Format:
PDF
Description:
Publisher’s version
Publication year
2008Source
Movement Disorders, 23, 7, (2008), pp. 958-63ISSN
Publication type
Article / Letter to editor
Display more detailsDisplay less details
Organization
Neurology
Journal title
Movement Disorders
Volume
vol. 23
Issue
iss. 7
Page start
p. 958
Page end
p. 63
Subject
DCN 2: Functional Neurogenomics; UMCN 3.2: Cognitive neurosciencesAbstract
Antineuronal antibodies (ANAs) have been implicated in the pathophysiology of postinfectious movement disorders, such as Sydenham's chorea. However, their relevance in other movement disorders--in the absence of infectious triggers--remains much disputed. We sought to assess the frequency of ANAs in idiopathic Parkinson's disease (IPD) and to explore whether a specific phenotype is associated with the presence of ANAs. For this purpose, we recruited 76 IPD patients, 9 patients with genetic parkinsonism, and 10 with one of the parkinson-plus syndromes. They were all subjected to a comprehensive clinical review. In addition, 50 patients with non-extrapyramidal neurological disease and 30 healthy blood donors served as control populations. Blood samples were tested for the presence of ANAs with Western blotting, using recombinant proteins of the three putative antigens (aldolase C, neuron-specific enolase, and pyruvate kinase M1). We found these antibodies in 11.8% of the 76 IPD patients, which differed significantly from healthy controls (0%, P = 0.043), but nonsignificantly from patients with genetic parkinsonism (11.1%), with a parkinson-plus syndrome (10%), or from neurological disease controls (4%). With respect to relevant disease characteristics, IPD patients with or without ANAs were indistinguishable, except for atypical disease features (mainly early falls or freezing and marked Pisa syndrome), which were more frequent in the ANA-positive IPD group. We conclude that ANAs do not play a role in the majority of patients with IPD, but might be relevant in the pathogenesis of IPD with atypical features.
This item appears in the following Collection(s)
- Academic publications [246625]
- Electronic publications [134196]
- Faculty of Medical Sciences [93367]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.