In vitro activities at pH 5.0 and pH 7.0 and in vivo efficacy of flucytosine against Aspergillus fumigatus.
Publication year
2008Source
Antimicrobial Agents and Chemotherapy, 52, 12, (2008), pp. 4483-5ISSN
Publication type
Article / Letter to editor

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Organization
Medical Microbiology
Former Organization
Radboud University Nijmegen Medical Centre
Journal title
Antimicrobial Agents and Chemotherapy
Volume
vol. 52
Issue
iss. 12
Page start
p. 4483
Page end
p. 5
Subject
N4i 2: Invasive mycoses and compromised host; NCMLS 1: Infection and autoimmunity; UMCN 4.1: Microbial pathogenesis and host defenseAbstract
The antifungal agent flucytosine was found to be active in vitro against Aspergillus fumigatus isolates when the MIC was determined at pH 5.0 instead of pH 7.0. The in vitro MIC at pH 5.0 corresponded to the in vivo efficacy of flucytosine monotherapy in a murine model of invasive aspergillosis.
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- Academic publications [227902]
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