Publication year
2008Source
Pediatric Neurosurgery, 44, 1, (2008), pp. 29-35ISSN
Publication type
Article / Letter to editor

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Organization
Gynaecology
Urology
Paediatrics
Surgery
Pathology
Neurology
Biochemistry (UMC)
Journal title
Pediatric Neurosurgery
Volume
vol. 44
Issue
iss. 1
Page start
p. 29
Page end
p. 35
Subject
DCN 1: Perception and Action; DCN 2: Functional Neurogenomics; EBP 2: Effective Hospital Care; IGMD 6: Hormonal regulation; IGMD 8: Mitochondrial medicine; IGMD 9: Renal disorder; NCEBP 12: Human Reproduction; NCEBP 14: Cardiovascular diseases; NCMLS 1: Immunity, infection and tissue repair; NCMLS 3: Tissue engineering and pathology; UMCN 3.1: Neuromuscular development and genetic disorders; UMCN 3.2: Cognitive neurosciences; UMCN 4.3: Tissue engineering and reconstructive surgery; UMCN 5.1: Genetic defects of metabolism; UMCN 5.2: Endocrinology and reproductionAbstract
BACKGROUND/PURPOSE: The aim of the study was to evaluate whether a collagen biomatrix is useful for delayed intrauterine coverage of a surgically created spina bifida in a fetal lamb. METHODS: In 20 fetal lambs, surgery was performed at 72 or 79 days' gestation. In 15 lambs a spina bifida was created surgically. In 8 lambs it was covered with a collagen biomatrix 2 weeks later and in 7 lambs it was left uncovered. Five lambs served as sham operated controls. Neurological examination was performed at 1 week of age and afterwards the lambs were sacrificed for further histological evaluation. RESULTS: None of the 5 surviving lambs with the defect covered showed loss of spinal function and the architecture of the spinal cord was preserved in 4 of the 5 lambs. In the uncovered group, 1 of the 4 surviving lambs had loss of spinal function, 5 lambs were available for histological evaluation and 4 of them showed disturbance of the architecture of the spinal cord. CONCLUSIONS: Collagen biomatrices can be used for intrauterine coverage of an experimental spina bifida and can preserve the architecture of the spinal cord. Neurological outcome is not different between fetuses with their spinal cord covered and fetuses with uncovered cords.
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- Faculty of Medical Sciences [80072]
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