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Publication year
2008Source
Netherlands Journal of Medicine, 66, 2, (2008), pp. 53-61ISSN
Publication type
Article / Letter to editor

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Organization
Internal Medicine
Nephrology
Journal title
Netherlands Journal of Medicine
Volume
vol. 66
Issue
iss. 2
Page start
p. 53
Page end
p. 61
Subject
IGMD 5: Health aging / healthy living; IGMD 7: Iron metabolism; IGMD 9: Renal disorder; NCEBP 14: Cardiovascular diseases; UMCN 2.2: Vascular medicine and diabetes; UMCN 5.1: Genetic defects of metabolism; UMCN 5.4: Renal disordersAbstract
The incidence of cardiovascular disease is markedly increased in patients with end-stage renal disease (ESRD). High serum cholesterol is widely recognised as a cardiovascular risk factor in the general population. However, in patients with ESRD high concentrations of cholesterol are associated with a better survival. This reverse epidemiology is, amongst others, caused by confounding due to malnutrition and chronic inflammation. In this population, treatment with statins to lower the serum cholesterol remains a matter of debate. In ESRD, LDL cholesterol is modified by increased oxidative stress. These altered LDL particles play a pivotal role in the development of atherosclerosis. Treatment with the antioxidant vitamin E has not equivocally been shown to be beneficial in this population. This review tries to put data from literature on dyslipidaemia and oxidative stress in ESRD in perspective.
This item appears in the following Collection(s)
- Academic publications [203856]
- Electronic publications [102283]
- Faculty of Medical Sciences [80326]
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