Defective interferon-gamma production in patients with hairy cell leukaemia.
SourceNetherlands Journal of Medicine, 66, 8, (2008), pp. 340-334
Article / Letter to editor
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Netherlands Journal of Medicine
SubjectN4i 1: Pathogenesis and modulation of inflammation; N4i 2: Invasive mycoses and compromised host; NCMLS 1: Immunity, infection and tissue repair; NCMLS 1: Infection and autoimmunity; NCMLS 2: Immune Regulation; UMCN 1.2: Molecular diagnosis, prognosis and monitoring; UMCN 1.4: Immunotherapy, gene therapy and transplantation; UMCN 4.1: Microbial pathogenesis and host defense; UMCN 1.2: Molecular diagnosis, prognosis and monitoring; UMCN 1.4: Immunotherapy, gene therapy and transplantation
BACKGROUND: Patients with hairy cell leukaemia (HCL) have an increased susceptibility to intracellular pathogens, such as mycobacteria and Listeria. Although several abnormalities of T-cell populations have been described in HCL, the effector mechanism responsible for the increased susceptibility to infections is not known. METHODS: Blood was collected from 11 patients with HCL and 22 age- and gender-matched volunteers. Proinflammatory cytokine production by freshly isolated mononuclear cells was stimulated with either lipopolysaccharide or various heat-killed microorganisms. Cytokine concentrations were assessed by specific ELISAs. RESULTS: We demonstrate that mononuclear cells harvested from HCL patients have a specific defect of IFNgamma production when stimulated with a broad panel of bacterial stimuli. In contrast, the production of other proinflammatory cytokines, such as TNF, IL-1beta and IL-6, did not differ between HCL patients and controls. CONCLUSION: The specific defect in IFNgamma production may play a role in the susceptibility of patients with hairy cell leukaemia towards intracellular pathogens.
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