Adiponectin multimer distribution in patients with familial combined hyperlipidemia.
until further notice
SourceBiochemical and Biophysical Research Communications, 376, 1, (2008), pp. 164-168
Article / Letter to editor
Display more detailsDisplay less details
Epidemiology, Biostatistics & HTA
Biochemical and Biophysical Research Communications
SubjectEBP 1: Determinants in Health and Disease; IGMD 5: Health aging / healthy living; IGMD 6: Hormonal regulation; NCEBP 14: Cardiovascular diseases; NCEBP 1: Molecular epidemiology; ONCOL 3: Translational research; UMCN 2.2: Vascular medicine and diabetes; UMCN 5.1: Genetic defects of metabolism; UMCN 5.2: Endocrinology and reproduction
Adiponectin is secreted from adipocytes in different multimers, of which the high molecular weight (HMW) form is supposed to mediate favorable metabolic and anti-atherogenic effects. We determined adiponectin multimers in 29 female and 22 male patients with familial combined hyperlipidemia (FCH) and 51 age-, gender-, and BMI-matched controls in relation to cardiovascular disease (CVD). We observed a clear sexual dimorphism of total adiponectin and its multimers. Female, but not male, FCH patients had significant lower total adiponectin and both HMW and low molecular weight (LMW) adiponectin than controls. The adiponectin sensitivity index (ASI), reflected by HMW/total adiponectin, and the LMW/HMW adiponectin ratio did not differ significantly between FCH females and control females. However, FCH females with CVD exhibited significantly lower ASI (34.2+/-10.1% vs 46.0+/-7.1%) and higher LMW/HMW ratio (1.5+/-0.8 vs 0.7+/-0.3) compared to FCH females without CVD, reflecting a more atherogenic adiponectin multimer distribution.
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.