Subject:
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EBP 1: Determinants in Health and Disease IGMD 5: Health aging / healthy living IGMD 6: Hormonal regulation NCEBP 14: Cardiovascular diseases NCEBP 1: Molecular epidemiology ONCOL 3: Translational research UMCN 2.2: Vascular medicine and diabetes UMCN 5.1: Genetic defects of metabolism UMCN 5.2: Endocrinology and reproduction |
Organization:
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Internal Medicine Health Evidence Endocrinology |
Former Organization:
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Epidemiology, Biostatistics & HTA
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Journal title:
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Biochemical and Biophysical Research Communications
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Abstract:
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Adiponectin is secreted from adipocytes in different multimers, of which the high molecular weight (HMW) form is supposed to mediate favorable metabolic and anti-atherogenic effects. We determined adiponectin multimers in 29 female and 22 male patients with familial combined hyperlipidemia (FCH) and 51 age-, gender-, and BMI-matched controls in relation to cardiovascular disease (CVD). We observed a clear sexual dimorphism of total adiponectin and its multimers. Female, but not male, FCH patients had significant lower total adiponectin and both HMW and low molecular weight (LMW) adiponectin than controls. The adiponectin sensitivity index (ASI), reflected by HMW/total adiponectin, and the LMW/HMW adiponectin ratio did not differ significantly between FCH females and control females. However, FCH females with CVD exhibited significantly lower ASI (34.2+/-10.1% vs 46.0+/-7.1%) and higher LMW/HMW ratio (1.5+/-0.8 vs 0.7+/-0.3) compared to FCH females without CVD, reflecting a more atherogenic adiponectin multimer distribution.
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