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Title: Adiponectin multimer distribution in patients with familial combined hyperlipidemia.
Author(s): Koenen, T.B. ; Tits, L.J.H. van ; Holewijn, S. ; Lemmers, H.L.M. ; Heijer, M. den ; Stalenhoef, A.F.H. ; Graaf, J. de
Publication year: 2008
Source: Biochemical and Biophysical Research Communications, vol. 376, iss. 1, (2008), pp. 164-168
ISSN: 0006-291X
DOI: http://dx.doi.org/10.1016/j.bbrc.2008.08.111
Publication type: Article / Letter to editor

Please use this identifier to cite or link to this item : http://hdl.handle.net/2066/69561   http://hdl.handle.net/2066/69561

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Subject: EBP 1: Determinants in Health and Disease
IGMD 5: Health aging / healthy living
IGMD 6: Hormonal regulation
NCEBP 14: Cardiovascular diseases
NCEBP 1: Molecular epidemiology
ONCOL 3: Translational research
UMCN 2.2: Vascular medicine and diabetes
UMCN 5.1: Genetic defects of metabolism
UMCN 5.2: Endocrinology and reproduction
Organization: Internal Medicine
Health Evidence
Endocrinology
Former Organization: Epidemiology, Biostatistics & HTA
Journal title:
Biochemical and Biophysical Research Communications
Volume: vol. 376
Issue: iss. 1
Page start: p. 164
Page end: p. 168
Abstract:
Adiponectin is secreted from adipocytes in different multimers, of which the high molecular weight (HMW) form is supposed to mediate favorable metabolic and anti-atherogenic effects. We determined adiponectin multimers in 29 female and 22 male patients with familial combined hyperlipidemia (FCH) and 51 age-, gender-, and BMI-matched controls in relation to cardiovascular disease (CVD). We observed a clear sexual dimorphism of total adiponectin and its multimers. Female, but not male, FCH patients had significant lower total adiponectin and both HMW and low molecular weight (LMW) adiponectin than controls. The adiponectin sensitivity index (ASI), reflected by HMW/total adiponectin, and the LMW/HMW adiponectin ratio did not differ significantly between FCH females and control females. However, FCH females with CVD exhibited significantly lower ASI (34.2+/-10.1% vs 46.0+/-7.1%) and higher LMW/HMW ratio (1.5+/-0.8 vs 0.7+/-0.3) compared to FCH females without CVD, reflecting a more atherogenic adiponectin multimer distribution.

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