Acute tryptophan depletion in healthy volunteers enhances punishment prediction but does not affect reward prediction.
Fulltext:
69537.pdf
Embargo:
until further notice
Size:
172.2Kb
Format:
PDF
Description:
Publisher’s version
Publication year
2008Source
Neuropsychopharmacology, 33, 9, (2008), pp. 2291-9ISSN
Publication type
Article / Letter to editor
Display more detailsDisplay less details
Organization
Psychiatry
Journal title
Neuropsychopharmacology
Volume
vol. 33
Issue
iss. 9
Page start
p. 2291
Page end
p. 9
Subject
DCN 1: Perception and Action; UMCN 3.2: Cognitive neurosciencesAbstract
Central serotonin (5-HT) has been implicated in emotional and behavioral control processes for many decades, but its precise contribution is not well understood. We used the acute tryptophan depletion procedure in young healthy volunteers to test the hypothesis that central 5-HT is critical for predicting punishment. An observational reversal-learning task was employed that provided separate measures of punishment and reward prediction. Under baseline, subjects made more prediction errors for punishment-associated stimuli than for reward-associated stimuli. This bias was abolished after central 5-HT depletion, which enhanced the ability to predict punishment while not affecting reward prediction. The selective potentiation of punishment prediction concurs with recent theorizing, suggesting that central 5-HT carries a prediction error for future punishment, but not for future reward (Daw et al, 2002). Furthermore, the finding highlights the importance of central 5-HT in resilience to adversity and may have implications for a variety of neuropsychiatric disorders including depression and anxiety.
This item appears in the following Collection(s)
- Academic publications [238430]
- Electronic publications [122512]
- Faculty of Medical Sciences [90359]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.