Lymphocyte subsets in peripheral blood of patients with moderate-to-severe versus mild plaque psoriasis.
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Publication year
2008Source
Archives of Dermatological Research, 300, 3, (2008), pp. 107-13ISSN
Publication type
Article / Letter to editor
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Organization
Dermatology
Journal title
Archives of Dermatological Research
Volume
vol. 300
Issue
iss. 3
Page start
p. 107
Page end
p. 13
Subject
N4i 1: Pathogenesis and modulation of inflammation; N4i 4: Auto-immunity, transplantation and immunotherapy; NCMLS 1: Immunity, infection and tissue repair; UMCN 4.2: Chronic inflammation and autoimmunityAbstract
In several studies peripheral blood T-cells have been quantified, yet few data are available on lymphocyte subsets in moderate-to-severe psoriasis (in terms of extent and activity of lesions) versus mild psoriasis. The objective is to compare lymphocyte subsets in peripheral blood of patients with moderate-to-severe disease (PASI-score > or =12) to patients with mild disease (PASI-score <12) and to healthy subjects. By means of flow cytometry method, lymphocytes in peripheral blood of 27 patients with psoriasis and 10 healthy controls were characterized. The absolute number of total lymphocytes was markedly decreased in patients with moderate-to-severe psoriasis as compared to patients with mild disease and normal subjects. Cellcounts of all analysed subsets were found to be increased in more severe psoriasis, except for CD8+CD45RO+ cells. The under-representation of CD8+CD45RO+ cells is compatible with the dynamics of acquired immunity, which requires a time log after the relapse of the lesions to differentiate from CD45RA+ naive cells.
This item appears in the following Collection(s)
- Academic publications [245054]
- Electronic publications [132354]
- Faculty of Medical Sciences [93209]
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