Publication year
2008Source
Journal of Biomaterials Applications, 22, 4, (2008), pp. 309-335ISSN
Publication type
Article / Letter to editor

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Organization
Dermatology
Journal title
Journal of Biomaterials Applications
Volume
vol. 22
Issue
iss. 4
Page start
p. 309
Page end
p. 335
Subject
UMCN 4.2: Chronic inflammation and autoimmunityAbstract
Porous PEGT/PBT implants with different physico-chemical characteristics were evaluated to identify its potential as biodegradable and biofunctional soft tissue filler. Implants (50 x 10 x 5 mm3) were implanted subcutaneously in mini-pigs and tissue response, tissue volume generated and its consistency were assessed quantitatively with a 52 weeks follow-up. The absence of wound edema, skin irritation, and chronic inflammation demonstrated biocompatibility of all implants evaluated. The hydrophobic implants induced the mildest foreign body response, generated highest amount of connective tissue and demonstrated a decrease in copolymer MW of 34-37% compared to 90% decrease of the hydrophilic implants. The rate and extent of copolymer fragmentation seems to be the determining factor of success of soft tissue augmentation using porous PEGT/PBT copolymer implants.
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- Academic publications [202669]
- Faculty of Medical Sciences [79975]
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