Effects of levetiracetam on spike and wave discharges in WAG/Rij rats
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SourceSeizure-European Journal of Epilepsy, 13, 8, (2004), pp. 591-594
Article / Letter to editor
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SW OZ DCC SMN
SW OZ NICI BI
Seizure-European Journal of Epilepsy
Effects of the novel anti-epileptic drug levetiracetam (50 and 100 mg/kg) on spike and wave discharges (SWDs) of WAG/Rij rats were studied. Levetiracetam decreased the incidence, average duration, total duration and peak frequency of the SWDs. There was no difference between the two doses. These results agree with results obtained in Genetic Absence Epilepsy Rat from Strasbourg (GAERS). Furthermore, the decrease of the SWD peak frequency might support the suggestions that levetiracetam might have a GABAergic mechanism of action.
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