Abstract
Background. Long-term results of minimal intervention strategies to cut down benzodiazepine use are not available.
Objective. To evaluate the relapse rate over a two-year period and to search for predictors of
relapse among patients who quit benzodiazepine use after receiving a discontinuation letter.
Methods. Baseline assessment and prospective monitoring of the medical records of 109 patients who quit long-term benzodiazepine use after a minimal intervention strategy in general practice.
Results. After 819 ± 100 days of follow-up, 53 (49%) patients had remained completely abstinent. Two independent predictors of relapse were identified by Cox regression analysis: use of more than 10 mg diazepam equivalent (RR = 2.4 [1.2 – 4.7]) and poor general health perception (RR = 0.98 [0.97 – 0.99]).
Conclusion. Short-term success rates after a minimal intervention were maintained well during long-term follow-up. High-dose users have the highest risk of relapse.
