Omission Evoked Potentials (OEPs) in rats and the effects of diazepam
Publication year
2002Source
Psychophysiology, 39, 2, (2002), pp. 229-235ISSN
Publication type
Article / Letter to editor
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Organization
SW OZ DCC SMN
Former Organization
SW OZ NICI BI
Journal title
Psychophysiology
Volume
vol. 39
Issue
iss. 2
Page start
p. 229
Page end
p. 235
Subject
Cognitive neuroscienceAbstract
We investigated whether evoked potentials to omitted stimuli could be measured in rats. Such an animal model would provide a measure of aspects of information processing concerned with expectancy and time estimation. In a first experiment, Omission Evoked Potentials (OEPs) were elicited in rats by omitting stimuli (10%) from a train of tone-pips with a fixed ISI (3 s). A control session consisted of omitting stimuli (10%) from a train of tone-pips with a variable ISI (2.5-3.5 s.). In a second experiment OEPs were measured in rats that received 4 mg.kg-1 diazepam or vehicle s.c. In the first experiment half of the animals showed an OEPs thad consisted of a late-latency positive wave, the other rats showed a slow negative drift. No OEPS were found in the control session. Rats showing OEPs consisting of a positive wave in Experiment 1 were passed to Experiment 2. In the vehicle condition of the second experiment, all rats showed OEPs. In the diazepam condition no OEPs were found. We found that OEPs can be measured in rats. In addition, OEPs are disrupted by diazepam. We propose that OEPs provide an elegant tool to elicit selectively endogenous EP components.
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- Academic publications [245262]
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- Faculty of Social Sciences [30344]
- Open Access publications [106238]
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