The interferon gamma gene in celiac disease: augmented expression correlates with tissue damage but no evidence for genetic susceptibility.
Fulltext:
59364.pdf
Embargo:
until further notice
Size:
219.6Kb
Format:
PDF
Description:
Publisher’s version
Publication year
2004Source
Journal of Autoimmunity, 23, 2, (2004), pp. 183-90ISSN
Publication type
Article / Letter to editor
Display more detailsDisplay less details
Organization
Nephrology
Rehabilitation
Journal title
Journal of Autoimmunity
Volume
vol. 23
Issue
iss. 2
Page start
p. 183
Page end
p. 90
Subject
UMCN 5.4: Renal disordersAbstract
Celiac disease (CD) is a complex genetic disorder characterized by gluten intolerance. The Th1 immune response, with a key position for interferon gamma (IFN-gamma), is an important determinant of intestinal remodeling in CD. We aimed at further ascertaining the role of IFN-gamma, either as a genetic factor in the etiology, or as a facilitator of disease initiation/progression. Duodenal biopsies were sampled across distinct histopathological stages of the disease, including refractory CD (RCD), and used to determine IFN-gamma gene (IFNG) expression by real-time RT-PCR. INFG expression correlated with the extent of tissue restructuring, reaching a 240-fold higher expression in total villous atrophy compared to healthy tissue. CD and RCD patients with similar lesions had comparable expression levels. Interestingly, patients in complete remission still had 7.6-fold residual over-expression. An INFG marker was tested in three cohorts of Dutch patients for both genetic linkage and association. Linkage analysis yielded no significant scores for IFNG or its flanking markers. In addition, IFNG allele frequencies were not differently distributed between cases and controls. Likewise, all alleles were randomly transmitted to affected children in parents-case trios. There is no evidence for IFNG as a predisposing gene in CD, despite its enhanced expression in patients in complete remission.
This item appears in the following Collection(s)
- Academic publications [245012]
- Electronic publications [132296]
- Faculty of Medical Sciences [93198]
Upload full text
Use your RU credentials (u/z-number and password) to log in with SURFconext to upload a file for processing by the repository team.